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But they work in totally different ways: Sermorelin therapy: stimulates the pituitary gland to release growth hormone, which increases IGF-1 and supports bone, muscle, and metabolic function Estrogen therapy: binds to estrogen receptors rather than growth hormone receptors, impacting many of the same tissues, including bones, muscles, and fat As women balance the symptoms that arise during perimenopause and midlife, finding the right solution varies based on personal needs, body type, and other health factors

PMID: 27675536

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Statistical analyses were carried out using GraphPad Prism software (version 10.4.1)

doi: 10.1007/s12031-010-9336-y 5