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Zinc is estimated to bind to around 3000 proteins in vivo, representing about 10% of the human proteome, 6 with over 3% of genes in human bodies encoding proteins containing zinc finger domains

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However, excess ROS is inherently cytotoxic [271], necessitating adaptive antioxidant responses in cancer cells to maintain redox balance [272]

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Moreover, NAC supplementation, which increases cellular thiols (Fig