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Furthermore, in vitro studies with dissected rabbit cataract lenses cultured with 25 mM lanosterol (dissolved in vehicle) and in vivo research with dogs administered intravitreal injections of 2 mg/ml lanosterol loaded nanoparticles every 3 days confirmed the effect of lanosterol in reducing cataract severity and increasing lens transparency by reversing protein aggregation (149)

Of these, the majority are membrane phospholipids, sphingolipids, and cholesterol (78, 81, 82)

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Nagoor Meeran et al., 2018)

Mechanistically, autophagy can be considered as protective or cytotoxic, relying on the cellular context, but in most cases, autophagy serves as a survival pathway promoting chemoresistance