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Among these complications, its impact on male reproductive health is increasingly gaining attention, as it may contribute to infertility and reduced reproductive potential in men [2]

The potent antioxidant activity of creatine could also protect mitochondrial DNA from ROS-mediated oxidative damage 543,544

Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression

PBMC, peripheral blood mononuclear cell

Nevertheless, future research should focus on examining temporal relationships between HPA axis function and immune-inflammatory or nitrosative stress pathways through biomarkers like TNF-, IL-10, TGF-, inducible NO synthase, NO production, protein nitrosylation, and bacterial translocation in ME/CFS patients to better understand their roles [79]