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Regeneration of tubular epithelial cells promotes recovery, whereas interstitial fibrosis and loss of renal capillaries are associated with progression to CKD (150)

47 In this scenario, administering an ammonia-lowering drug in NAFLD could reduce disease progression by scavenging non-urea ammonia and thereby reducing the activation of HSCs

* Correspondence: Yunzhu Yang, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

however, betaine was shown to restore cerebrospinal fluid SAMe levels to normal and to prevent the progress of neurologic symptoms in all patients in whom it was tried