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The increase in GSH content can be achieved from GSSG through GR catalyzation or de novo biosynthesis through the -glutamyl cycle

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Centrally, PNIs lead to retraction of synaptic inputs from motoneuron somata and dendrites (Alvarez et al., 2011

Among well-known senomorphic compounds, telomerase activators [120], caloric restriction diets [121] and mimetics [122], proteasome activators [123], autophagy activators [124], antioxidants [125], mTOR inhibitors [126], sirtuin activators [127], and anti-inflammatory agents targeting inflammaging /senoinflammation [128] can be mentioned

Furthermore, Mengchen et al.s investigation, which examined fecal DNA from experimental groups both before and after probiotic treatment, found that A