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PEGylated Liposome and Conventional Liposome, source: DOI:10.3390/ijms20194706 PEGylation, the covalent linking of PEG chains, changes the absorption of the protein corona on the liposome surface, significantly prolongs the circulation time of liposomes, improves the biodistribution of drugs, and achieves enhanced passive targeting of tumors by exploiting the enhanced permeability and retention (EPR) effect at the tumor site

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This characteristic can be exploited for cancer therapy by depleting amino acid supplies, blocking uptake by transporters, and inhibiting biosynthetic enzymes