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Machado-Santos, J

Post-viral gut dysbiosis (an imbalance in the intestinal microbiome) frequently leads to increased intestinal permeability, or "leaky gut." When microbial metabolites and toxins escape the digestive tract and enter the bloodstream, they trigger a systemic immune response

This tolerogenic environment ensures that the liver can process microbial signals from the gut without triggering pathogenic immune responses [21, 44] (Fig