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involving a SnCl 2 mediated Friedlander synthesis followed by Curtius rearrangement and deprotection with subsequent alkylation, as exemplified with the preparation of cation 2j (Scheme 3)

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Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer

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Since your body cannot synthesize Vitamin B12 on its own, it relies entirely on external sources