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PEM, which is characterized by an exacerbation of symptoms following physical or cognitive exertion, is also observed in FM and may be related to increased pain severity post-exertion (Barhorst et al., 2013)

Within the TCA cycle, succinate is converted into fumarate by the succinate dehydrogenase (SDH) which represents the respiratory ETC complex II (CII) 73 (Supplementary Fig