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In addition, enzymes, such as xanthine oxidase, NADPH oxidase (NOX), and myeloperoxidase (MPO), become overtly hyperactive during reperfusion and significantly contribute to the production of ROS (Sasaki and Joh, 2007

Determinants of protein retention characteristics on cation-exchange adsorbents

Collectively, these findings support a multifaceted role for TH in maintaining ECM homeostasis, and their dysregulation in hypothyroidism provides a mechanistic link to MAFLD development

(Rateb et al., 2017

However, studies of this type should be considered preliminary because the study lacked adequate control, including no randomization or placebo