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This inflammatory response induces oxidative stress within the tooth, leading to the degradation of enamel, dentin, pulp, and cementum

Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability

This hypothesis is supported by recent observations including accumulation of p53 in the mitochondrial matrix under oxidative stress 57 and a report from Velu et al