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Although a subset of patients with TNBC responds to immunotherapy, such as programmed cell death ligand 1/programmed cell death protein 1 (PD-L1/PD-1) blockade, the high heterogeneity of TNBC results in many patients exhibiting immunosuppressive cold tumor phenotypes, rendering immunotherapy less effective [7, 8]

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Patients with IBS and PCS may exhibit symptoms of postural orthostatic tachycardia syndrome (POTS), abnormal heart rate variability, and heightened visceral or systemic hypersensitivity

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