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The most common reasons are reducing GI side effects during titration and stretching supply when access is limited

doi:10.1089/thy.2010.0245

The alteration of conductivity on adding CAR to 0.02 mol/kg hydrogenated soya phosphatidylcholine (HSC) or PEG-40 stearate (PEGS) solution was investigated using a conductivity meter, and the results are shown in Fig

Clin Pharmacol Ther 39, 313-7 (1986)

One study reported a nonsignificant positive trend in the correlation between the magnitude of decrease in IGF-I levels and the magnitude of decrease in cortisol levels in 78 patients with MDD during 6 weeks of antidepressant treatment 39