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Importantly, combination of metformin and radiation significantly increased cell death, when compared to irradiated vehicle controls, highlighting the potential role for altered cell death in the metformin-mediated radiosensitisation of these cell lines

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Ongoing trials explore its efficacy in syndromic obesities (Bardet-Biedl, Alstrm syndromes) and epigenetic dysregulations of the melanocortin pathway [482]

TKIs, tyrosine kinase inhibitors