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Each component is associated in published preclinical literature with distinct mechanistic pathways, and the blend format allows laboratories to prepare all four under matched conditions for parallel single-agent and combined-arm experiments

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The injections offer a localized approach, giving relief exactly where the pain originates, unlike oral pain medications that affect the whole body

mean age 40[SD 11.1], 59% female): 37 presymptomatic mutation-carriers (no symptomatic ICH), three symptomatic mutation-carriers (one symptomatic ICH), eight 50%-at-risk participants and 18 controls Among 37 presymptomatic mutation-carriers, 23(62%) had WMH in a multi-spot pattern, 28(76%) severe CSO-EPVS, 17(46%) microbleeds, and 8(22%) macrobleeds

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