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In this context, radio- and chemo-resistant GSCs present a metabolic adaptation presenting a reduced glucose dependence, an improved lipid catabolism, ROS, mitogen-activated protein kinases (MAPKs) activity, and NAD + level, and an amplified SIRT1/PGC1 axis that promotes autophagy, resulting in an increase in the maintenance and repair machinery (Ye et al., 2013)

Emerging evidence suggests that amino acid metabolism plays a crucial role in the pathogenesis of pulmonary fibrosis

CAP acts on the large ribosomal subunit (LSU) by inhibition of peptide bond formation, thereby stalling mitoribosomes resulting in loss of mitochondrial translation with subsequent loss of mitochondrial-encoded respiratory chain complexes (Figs

Nuclear DNA leakage is categorized by its components, which mainly include cytosolic micronuclei, cytoplasmic chromatin fragments (CCFs) from senescent cells, retrotransposon [42]