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However, as pointed out by Hertz decades ago (Hertz 1979), astrocytes must possess a significant oxidative metabolic capacity in order to facilitate highaffinity uptake and subsequent metabolism of glutamate and GABA

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This implies that GSH levels may be used as a useful predictive marker to identify patients who have an elevated risk of developing these chronic conditions and may also offer a novel way to delay or even outright arrest disease progression by replenishing endogenous GSH using simple dietary modifications and lifestyle changes at the earliest possible stage when such interventions are most beneficial

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By inhibiting TGF- pathways and reducing collagen deposition, they protect podocytes and endothelial cells from injury, slowing CKD progression

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