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Immune Checkpoint Blockade in Cancer Therapy

10.1002/jcb.26398 J

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control ) mL (30 g/ diosmin ) mL (60 g/ diosmin ) mL (30 g/ bromelain ) mL (60 g/ bromelain 8 10 12 14 Trolox equivalent [nmol/mg Hb] control (30 g/mL) diosmin (60 g/mL) diosmin (30 g/mL) bromelain (60 g/mL) bromelain 8 10 12 14 thiol group [nmol/mg Hb] *** * control ) mL (30 g/ diosmin ) mL(60 g/ diosmin ) mL (30 g/ bromelain ) mL(60 g/ bromelain 0.5 1.0 1.5 2.0 GSH [nmol/mg Hb] *** * control (30 g/mL) diosmin (60 g/mL) diosmin (30 g/mL) bromelain (60 g/mL) bromelain 800 900 1000 1100 1200 1300 amino group [nmol/mg Hb] Figure 3

Conditioning studies overexpressing Irs2 enhanced cue-related drug-seeking for cocaine, while silencing Irs2 led to aversion or reduced preference for opiates, particularly in the ventral tegmental area (VTA) [59,60,61]