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Tirzepatide population pharmacokinetics and exposure Schneck 19-study pooled popPK (CL/F 0.061 L/h, half-life 5.4 d, accumulation 1.7x, body-weight covariate +22% at 70 kg / -33% at 120 kg)

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Combination of AAVmediated NUPR1 knockdown and trifluoperazine induces premature senescence in human lung adenocarcinoma A549 cells in nude mice