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Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies

Nevertheless, the utilization of metformin during pregnancy is typically determined following a collaborative evaluation of the potential risks and benefits by obstetricians and reproductive endocrinologists in current clinical practice

Total symptom score decreased significantly compared to placebo across treatment groups of all doses 600-1800 mg/d oral ALA, yet there was a dose-dependent increase in nausea, vomiting, and vertigo, and therefore the lowest dose of oral ALA (600 mg/d) is recommended