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Furthermore, several studies have associated ANGPTL3 function with disease phenotypes, such as obesity and diabetes at an observational level 26,30

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1 Introduction Psoriasis, a chronic inflammatory skin disease, affects an estimated 125 million individuals globally, with prevalence rates varying among ethnic groups, typically ranging from 0.33% to 0.6% ( Thymoquinone (TQ), a bioactive compound of Nigella sativa seeds, has emerged as a therapeutic candidate for various diseases due to its diverse pharmacological properties ( Therefore, in light of the limitations associated with current psoriasis therapies and the promising preclinical data on TQs anti-psoriatic effects, this review comprehensively evaluates the existing scientific knowledge regarding the therapeutic potential of TQ for psoriasis

The analysis of root mean square deviation (RMSD, segment distances and positions, tilt angles and radial distribution function g(r) was carried out using VMD software 58 (version 1.9.4)