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Nava Mesa, B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin, CNS Neurosci

Interestingly, activation of AMPK in the hypothalamus promotes food intake behavior (231)

[2] Supplements are commonly taken orally but may be administered via intramuscular injection to treat deficiencies

Nature 441, 537541

B12 shots can be especially helpful if you are older, do not eat animal products, have conditions that impact nutrient absorption, or take medications that interfere with nutrient absorption