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Among the tested alkaloids, speciogynine induced the strongest LLR effect with an ED 50 value of 23 mol/kg, followed by paynantheine (26 mol/kg) and mitragynine (62 mol/kg)

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A total of 2985 DEGs were identified in leaves exposed to SD, including 1238 upregulated and 1747 downregulated genes (Figure 2A)

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