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The typical plasma carnitine concentration is ~4060 M 26,27 , indicating that hOCTN2 operates close to saturation under physiological conditions, which would likely maintain steady carnitine uptake into the cell

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Srensen, M

9 , e0111821 (2021)

Enzymatic methods such as cyanobactin macrocyclases, split-intein systems, and sortase-mediated ligation offer site-specific and traceless cyclization under mild conditions