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The pathway leads to the generation of several sulfur metabolites, which include cysteine, GSH and the gaseous signalling molecule hydrogen sulfide (H 2 S)

Lysates were clarified by centrifugation, and the resulting supernatant was incubated with 1 mL of Ni-NTA Agarose (Qiagen, 30210) for 1 h at 4 C

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Furthermore, sesamin-treated mice maintained higher levels of endogenous antioxidants for example, superoxide dismutase (SOD) activity was increased relative to untreated MPTP mice, and striatal TH levels were better preserved, indicating reduced dopaminergic neuron damage (66)

FIGURE 1 2.2 Search strategy A systematic search of scientific literature was conducted in the Web of Science (Core Collection), Scopus, and PubMed databases, including studies published up to November 2025 without country restrictions