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Heteromers DR-DR Heteromers D1-D2R Heteromers Activation of the Gq-coupled D1-D2R heteromers in striatal neurons results in PLC-dependent intracellular calcium release, thus activating calmodulin-dependent protein kinase II (CaMKII)/Mutations of the methyl-CpG binding protein 2 (MeCP2)/brain-derived neurotrophic factor (BDNF) pathway (49)

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Evaluations between 14 to 21 days after starting treatment showed improvement in MDS-UPDRS-IV ( P = 0.001), including duration ( P = 0.001) and severity of dyskinesia ( P = 0.003)

Topoisomerase II inhibitors in AML: past, present, and future