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If we consider that Cd stimulates autophagy, the increase in the level of SQSTM1 remains surprising but could be explained by the fact that Cd activates ERK1/2 in cells with very low level of p-ERK1/2, and that RAF1/Raf-MAP2K/MEK-MAPK/ERK signaling can stimulate SQSTM1 transcription (Klionsky et al

This further supports the notion that promoting complete mitophagic flux, rather than just the initiation of mitophagy, could be critical in mitigating pancreatic inflammation and damage in AP

furthermore, they are low in fat and exhibit a relatively elevated level of carbohydrates and fiber, with the presence of fat-soluble vitamins and ergosterol making mushrooms the exclusive vegetarian source of vitamin D (51)

This overlap suggests that FOXO4s activation by oxidative stress and inflammation might follow similar mechanisms, pointing to a broader role of FOXO4 in stress and immune response contexts