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In turn, oxalate promotes steatosis in hepatocytes by inhibiting peroxisome proliferator-activated receptor- (PPAR) transcription and fatty acid -oxidation and induces monocyte chemotaxis via CC motif chemokine ligand 2

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10.3389/fncel.2015.00021 Front

Forsythiaside a alleviated carbon tetrachloride-induced liver fibrosis by modulating gut microbiota composition to increase short-chain fatty acids and restoring bile acids metabolism disorder

Thus, serum LDH levels may serve as a prognostic indicator in the future clinical use of cuproptosis-related medications, helping to assess the potential effectiveness of these drugs