MannWhitney U test result of the group comparison is shown in each panel
A majority of the included studies assessed PLC versus placebo (11 studies, 1395 participants), and one study assessed propionyl L-carnitine (PLC) versus L-carnitine (one study, 26 participants)
Furthermore, several studies lacked rigorous dose-response analyses or appropriate positive/negative controls to validate the specificity of the observed microbiome shifts
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