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For example, patients who have severe joint damage might find limited relief from injections, making them candidates for more advanced treatments like surgery

Commun Biol 7:116

Any elderly patient experiencing new or worsening neurological symptoms despite B12 treatment should be referred back to their GP for reassessment, as alternative diagnoses must be considered

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Niacin can produce a variety of GI effects, such as nausea/vomiting, abdominal pain, diarrhea, bloating, dyspepsia, or flatulence, when taken in large doses