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Phase Dual escalation 3 Weeks 21-24 Tirzepatide 12.5 mg/week Cagrilintide 1.7 mg/week Notes Approach maintenance

Acknowledgments The authors would like to acknowledge the support of Zoetis in the ideation of this study

It is a temporary condition characterized by the cessation of normal bowel motility, leading to symptoms such as abdominal discomfort, nausea, vomiting, and inability to pass stool or gas

It also possesses antioxidant properties, potentially through its ability to scavenge free radicals (Kirsch and De Groot, 2001), thereby mitigating oxidative stress

To provide consistent and repeatable findings, it is essential to determine the ideal dose of any chemical being tested