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Adequate B1 supports peripheral nerve function and prevents complications of deficiency, such as neuropathy and Wernicke-Korsakoff syndrome in severe cases

That means getting the following daily amounts

I do think the high folate w/ the (absent?) B12 is suspicious

Most physicians suggest holding off, or at least being extra cautious, while you are still titrating up to your target dose

Certain conditions, such as pregnancy or Addison's disease (decreased function of the adrenal gland), may cause a greater production of melanin and hyperpigmentation