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This bidirectional regulatory loop may act as a hot spot ensuring proper transitions of NSCs between quiescence, proliferation, and differentiation under oxidative or inflammatory stress

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In addition, extracellular lactate stabilizes HIF-2, and HIF-2 then transactivates MYC, increasing the levels of glutamine transporters and GLS1, in turn resulting in increased glutamine catabolism 72

The pH was then readjusted to 4.0 by addition of 6 M NaOH and the reaction mixture was stirred under inert atmosphere at 37 C for 16 h

The cyproterone component decreases sebum production by the sebaceous glands by blocking peripheral androgen receptors