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BDNF, brain-derived neurotrophic factor, is the central signaling molecule in neuronal survival, synaptic plasticity, and neurogenesis

What changes is the chemistry at the ends of the peptide, and those changes affect how long the molecule survives in the body, how much of it actually gets where its going, and (theoretically) what dose you need to use

In a convenience sample of deceased NFL football players who donated their brains for research, 110 of 111 had neuropathological evidence of CTE, suggesting that CTE may be related to playing football [note that participation in the brain-donation program was likely motivated by players and their families awareness of links between head trauma and CTE

The ones who see the most consistent results are the ones who treat the injection protocol as part of the treatment, not an afterthought to it