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Jared Prevette, senior, Deans List, College of Education and Human Sciences, secondary education and coaching

Some aspects, including DNA methylation and histone modification, have been recently described by Sharma et al

Patients should be assessed on disease activity, stability, and treatment intensity, and then categorized roughly as high, moderate, or low risk with respect to Ramadan fasting (Figure 1): High Risk Fasting Not Advised: This group includes patients with severe, active, or unstable disease where fasting is likely to cause harm

DISSECTION P938 - ESOC25-2421 CADASIL Argentine Registry (CADASILar): Establishing a Harmonized Clinical Protocol preliminary data Julieta Rosales 1 , Carolina Ardohain 2 , Juan Lopez 3 , Fabio Gonzalez 4 , Julian Alonso 5 , Valentin Selvaggi 6 , Diana Cristalli 7 , Ismael Calandri 2 1 Clinica Sagrada Familia-ENERI, Buenos Aires, Argentina, 2 FLENI, Buenos Aires, Argentina, 3 Sanatorio Los Arcos, Buenos Aires, Argentina, 4 Hospital Italiano de Bs As, Buenos Aires, Argentina, 5 Hospital Posadas, Buenos Aires, Argentina, 6 Hospital Ramos Meja, Buenos Aires, Argentina, 7 Centro Jesi, Buenos Aires, Argentina Background and Aims: CADASIL, a leading monogenic small vessel disease caused by NOTCH3 mutations, manifests with migraines, strokes, and cognitive decline