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Users often observe texture and tone shifts within 4 to 8 weeks, while more significant changes in density and wrinkles typically appear between 8 to 12 weeks

It is released from the extracellular matrix during tissue injury specifically cleaved from SPARC (Secreted Protein Acidic and Rich in Cysteine) and the alpha 2(I) chain of type I collagen.[2] Age-related decline: Plasma concentration declines from approximately 200 ng/mL (10 M) at age 20 to roughly 80 ng/mL by age 60

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Additionally, it has antioxidant effects and can modulate oxidative stress, which helps maintain cellular health and reduce signs of aging