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Oxidation status Liver lipid peroxidation was evaluated by measuring malondialdehyde (MDA) levels using a thiobarbituric acid kit, while total antioxidant capacity (TAOC) was assessed via the ferric reducing antioxidant power (FRAP) method, both performed according to the manufacturers instructions (Nanjing Jiancheng Bioengineering Institute)

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[DOI] [PMC free article] [PubMed] [Google Scholar] (377).Matsumoto A

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Patients were randomized (2:1) to one of the following treatment arms: Pemetrexed 500 mg/m2, pembrolizumab 200 mg, and investigators choice of cisplatin 75 mg/m2 or carboplatin AUC 5 mg/mL/min intravenously on Day 1 of each 21-day cycle for 4 cycles followed by pemetrexed 500 mg/m2 and pembrolizumab 200 mg intravenously every 3 weeks