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ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator

Journal of Clinical Orthopaedics and Trauma , 15, 145151

doi: 10.1159/000470814 49 Alvarez-MonMAOrtegaMAGarca-MonteroCFraile-MartinezOLaheraGMonserratJet al

A recent study suggested that there may be multiple reasons for remyelination failure in MS patients, according to lesion stage: in a subset of active lesions, a lack of myelin sheath formation was observed despite the presence of mature OLGs, whereas in inactive lesions, OLG loss and a hostile microenvironment were identified as the major causes of remyelination failure (He et al., 2020)

Interestingly, external iron supplementation has been shown to inhibit M1 polarization by downregulating proinflammatory mediators and iNOS expression through STAT1 inhibition, without impairing phagocytic capacityM1 (108)