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In situations where a high dose is needed, or where injection is the only option, the B12 shot is used

When B12 levels fall below normal ranges, the bone marrow produces abnormally large, immature red blood cells called megaloblasts, which cannot function effectively to transport oxygen throughout the body

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Our data, consistent with the literature [32], show that chronic duration of therapy, higher cumulative metformin dose and concomitant PPI therapy (Table 1) increase the risk of vitamin B 12 deficiency

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