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B6 also plays an important role in immune functions and is also a bio-marker of inflammation with its down-regulation being associated with severe inflammation (16)

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doi: 10.1182/blood-2015-05-644591 74 XuTStewartKMWangXLiuKXieMRyuJKet al

Bonkovsky and co-workers have demonstrated that CoPP, and ZnMP upregulate HO-1 expression through the repression of Bach1 and upregulation of the Nrf2 protein (Shan et al., 2006