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ArbeloEProtonotariosAGimenoJRArbustiniEBarriales-VillaRBassoCet al2023 ESC guidelines for the management of cardiomyopathies

9jl and Supplementary Table 3)

Decreased levels of red blood cell reduced glutathione (RBC-GSH) and increased levels of oxidized glutathione have been observed in hypertensive patients, resulting in an elevated ratio of oxidized to reduced glutathione compared to controls

The initial burst is likely due to presence of HSP on the outermost surface of NPs, while the sustained release indicates that the drugs release from the inner polymer phase