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Phytother Res 36(3):13861401

The clinical manifestations can vary from multi-organ failure in the neonate with a fatal outcome to late-onset symptoms associated with significant disabilities

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Conversely, genera such as Lachnospiraceae UCG-001 , Ruminococcus-1 , Candidatus Arthromitus , Enterobacter , and Lactobacillus exhibited positive correlations with these parameters [189]

2 FDA Breakthrough Therapy Designation is intended to expedite the development and review of medicines with early evidence of potential clinical benefit in serious diseases and to help ensure that patients receive access to medicines as soon as possible