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L-serine can also be generated through the folate cycle via serine hydroxymethyltransferase (SHMT) 1 localized in the cytoplasm (Fig

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2.1.1 Microgliathe first line of defense Microglia are frequently found as resident immune cells in the central nervous system (CNS) and affect pathological processes such as neuronal healing, antigen presentation, and poststroke inflammation ( 2.1.2 Astrocytesdouble-edged sword for modulation The most prevalent glial cell type in the CNS, astrocytes, has an essential function ( in vivo and in vitro research should be conducted to explore astrocyte pathways in the case of IS