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Measurement of Cytokine Secretion, Intracellular Protein Expression, and mRNA in Resting and Stimulated Peripheral Blood Mononuclear Cells

When it becomes oxidized, it can break down yielding a large variety of compounds including a, -unsaturated aldehydes (Poli et al., 1987) These are toxic compounds because they can react with proteins in the cells, particularly at cysteine, lysine or histidine by either Michael addition to the carboncarbon double bond or by Schiff base formation at the carbonoxygen double bond (Esterbauer et al., 1991

It utilizes an aldehyde bisulfite to covalently bind to C145 (refs 94,95 )

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The authors evaluated 62 clinical trials which reported following the KD, and only 25 had an acceptable ketogenic ratio