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Hyperglycemic conditions also induce TNF expression in cardiomyocytes, which alters DNMT activity and promotes methylation of the SERCA2a gene promoter, leading to reduced SERCA2a expression, calcium overload, and subsequent diastolic heart failure [121]

Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation

Moreover, thyroid cancer risk was observed to be higher in obese people, and female patients with type 2 diabetes mellitus (T2DM) are more likely to have the extra-glandular invasion of PTC than male T2DM patients (126, 127)

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Reduced glutathione is significant in various health contexts: Oxidative Stress: A deficiency in GSH can lead to increased susceptibility to oxidative damage, contributing to conditions like cancer, cardiovascular diseases, and neurodegenerative disorders