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This article further summarizes the potential of oral interventions for periodontitis (such as mechanical debridement and local/systemic antimicrobial therapy), microbiota modulation methods (such as probiotics, prebiotics, and fecal microbiota transplantation), and multidisciplinary collaborative comprehensive treatment strategies in improving microbial homeostasis and alleviating depressive symptoms

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For instance, mitochondrial ROS activate the NLRP3 inflammasome to drive pyroptosis, while TGF- and ROS form a self-amplifying loop that accelerates fibrotic progression

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Another pathway in inhibition of TGF--mediated EMT by curcumin is that this plant derived-natural compound suppresses Smad2 phosphorylation, its nuclear translocation and interaction with promoter of Snail (Cao et al., 2017)