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42 Overall, there is insufficient evidence to support a GFD for all AD patients, and official guidelines for patient selection have not yet been issued

Similarly, Van Langendonckt et al (54) demonstrated iron deposits in endometriotic lesions, and experiments in mice revealed that injecting menstrual effluent containing red blood cells into mice led to substantial iron accumulation in lesions, whereas iron deposits were less prominent in injections containing only endometrial cells or serum

Res., 1-155-176

This cascade further leads to lipid peroxidation, mitochondrial dysfunction, disruption of cell membrane integrity, and ultimately, cell apoptosis [21, 22]

High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy