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Much of the supporting research summarized in peer-reviewed literature relies on animal studies, such as GLP-1 receptor-knockout mice and rodent injection trials, rather than large-scale human trials, and peptide-based drugs overall are described as rarely used in real-world patient care because of lingering questions about safety, effectiveness, and inadequate insurance coverage

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Fat Loss Without Muscle Loss Traditional dieting and aggressive fat burners can trigger catabolism, leading to the loss of lean muscle mass

This applies to metformin, glipizide, and all other oral diabetes medications

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