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4 Biochemical characterization of SLC33A1-mediated GSSG binding and transport

Seventy-one hits were identified to bind at the substrate-binding site, and three hits were found to bind near the dimer interface

Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinsons disease

There has been substantial clinical evidence that the survival of patients with advanced cancer is improved by immune checkpoint inhibitors (ICIs), especially by blocking the immune checkpoint axis involved in programmed cell death 1 (PD-1) and programmed death ligand 1 (PD-L1) 195,196

The stress of living with a genetic condition like hemochromatosis can itself contribute to oxidative stress and inflammation